Modularity and Dynamics of Cellular Networks
نویسندگان
چکیده
منابع مشابه
Modularity and Dynamics of Cellular Networks
Understanding how the phenotypes and behaviors of cells are controlled is one of the major challenges in biological research. Traditionally, focus has been given to the characterization of individual genes/proteins or individual interactions during cellular events. However, many phenotypes and behaviors cannot be attributed to isolated components. Rather, they arise from characteristics of cell...
متن کاملNetworks, dynamics, and modularity.
The identification of general principles relating structure to dynamics has been a major goal in the study of complex networks. We propose that the special case of linear network dynamics provides a natural framework within which a number of interesting yet tractable problems can be defined. We report the emergence of modularity and hierarchical organization in evolved networks supporting asymp...
متن کاملSpontaneous emergence of modularity in cellular networks.
Modularity is known to be one of the most relevant characteristics of biological systems and appears to be present at multiple scales. Given its adaptive potential, it is often assumed to be the target of selective pressures. Under such interpretation, selection would be actively favouring the formation of modular structures, which would specialize in different functions. Here we show that, wit...
متن کاملNetworks in nature : dynamics, evolution, and modularity
In this thesis we propose some new approaches to the study of complex networks, and apply them to multiple domains, focusing in particular on protein-protein interaction networks. We begin by examining the roles of individual proteins; specifically, the influential idea of ‘date’ and ‘party’ hubs. It was proposed that party hubs are local coordinators whereas date hubs are global connectors. We...
متن کاملUnderstanding modularity in molecular networks requires dynamics.
The era of genome sequencing has produced long lists of the molecular parts from which cellular machines are constructed. A fundamental goal in systems biology is to understand how cellular behavior emerges from the interaction in time and space of genetically encoded molecular parts, as well as nongenetically encoded small molecules. Networks provide a natural framework for the organization an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Computational Biology
سال: 2006
ISSN: 1553-734X,1553-7358
DOI: 10.1371/journal.pcbi.0020174